IgG4 intolerance testingWhy we use IgG4 antibodies
IgG4 Antibodies. They give a more accurate reading.
Why do we test for IgG4 using Blood in our Intolerance Test
IgG1 and IgG4 – What is the process?
Testing for IgG4 over IgG1 or total IgG is a massive advantage for Test Your Intolerance. Testing for IgG4 leads to a reduced number of false-positives, allowing us to deliver much more experienced and targeted results.
Out of the four subclasses of IgG, the most commonly tested are IgG1 and IgG4. These are produced in response to food antigens which means we can identify their intolerances a lot easier. As IgG1 antibodies are first responders, we can reach new food antigens by joining the antigens and forming complexes.
From there, these complexes are quickly destroyed by immune system cells which are called macrophages. These IgG1 antibodies can then additionally activate further immune reactions, and as such, they complement cascade and inflammation.
What is an IgG4 Antigen Complex?
Many people are not aware that intolerances can be developed and caused by overindulgence on a certain item. If the body is continuously exposed to a certain item or antigen, then this could lead to a class switch from IgG1 to IgG4 antibody production.
So, what happens?
These IgG4 antigen complexes do not then activate the complement cascade.
Why does this happen?
Because complexes of IgG4 and food antigens are very stable, and alterations in any sort of structure can lead to new antigen forms.
When identifying which items you have an intolerance to, it is important that you understand why your body reacts to the item this way. Measuring your IgG4 levels means you can either rule out or confirm an intolerance as the cause of your symptoms. Order your elite blood test today.
Take a look below at how IgG1 can produce an IgG4-antigen-complex, which in turn creates a whole new cycle, going something like this:
IgG1 (class switch) → IgG4 → IgG4-antigen-complex → modification → IgG1 → IgG4
Why is IgG4 the marker of Chronic Food-Immune Reactions
IgG4 is the marker of Chronic Food-Immune reactions and as a result of this, the complexes will only get larger. From here, these larger complexes are able to activate the complement cascade, and will therefore initiate inflammatory responses within the body. Blood Intolerance testing allows us to detect these complexes.
An inflammatory response to a food is the main cause of many symptoms. If you have a food intolerance then this will be the main cause of any symptoms which you may experience. From here, these complexes can also be deposed in tissues or organs, and this leads to plenty of damage, causing the most uncomfortable and nuisance symptoms to an individual. This sequence of events is thought to be the most common way in which individuals develop an adverse reaction to foods, and this is something that they consume on a regular basis.
IgG1 antibodies show themselves to be more adhesive and readily bind to any antigens which may come their way. This then raises the prospect of cross-reactivity, meaning there is a number of false-positive results in testing.
Why is testing IgG4 levels an advantage for us?
Testing both IgG1 and IgG4 can sometimes lead to many unnecessary food eliminations. Presenting itself as an antibody, it is a more clinically applicable marker of chronic food-immune reactions.
This also includes possible intestinal hyperpermeability. So, compared against each other, between IgG1 and IgG4, IgG4 measurements are less likely to produce false-positives on in-vitro tests. When measuring all ranges of IgG, or total IgG, it is more likely that these antibodies will result in a higher rate of false-positive reactions.
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